Oaf generation and zincic lack are concerned

Human nutrition is the nutrient material that shows airframe undertakes life activity place needs, modern medicine thinks, the mankind has material of 7 big nutrition, namely: Protein, adipose, carbohydrate, water, vitamin, mineral with prandial fiber.

The microelement inside the human body that heretofore already discovered adds up to 41 kinds, among them 15 kinds need for human place. Except foregone it has important biology active and special nutrition outside, microelement is in the research that the Yo of immunity, genetic, prepotent actor, happening that defers consenescence and disease develops a field, already became in recent years bound of domestic and international medicine a very active domain. According to a large number of document: Clinical on a variety of diseases and microelement unbalance are concerned. The dependency of microelement and human disease already was taken seriously increasingly. At present our country person is short of zinc, Selenium, iodic, iron quite general, existing " lack, sicken, more lack " vicious circle.

　　 Microelement zinc is life element

In 15 foregone kinds of indispensible microelement, zinc almost consist in is all in type living things, microelement zinc is life element, zinc regards human airframe as one of indispensible microelement, it is the nutriment that has important physiology function. Zinc is next to iron in the content inside human body, reside the 2nd, embedded zinc quantity is airframe 2, 2.5g, chroma of normal and serous zinc is 12, 20 μ Mol/L. The zinc in plasma is united in wedlock with albumen mostly, main with albumin, α 2, globulin and turn iron albumen is united in wedlock. Zinc has in the main biology action inside airframe: Maintain biomembrane normal structure and function; Participate in nucleic acid and protein metabolization, with gene expression is concerned; Participate in form enzymaticly with activation, the synthesis that participates in hormone and secrete, affect hormone and the couple that its accept put oneself in another's position; And be concerned with thymus element and cellular factor. Accordingly, zinc is human body grows development, reproduction, genetic, immunity, endocrine, nerve, humoral the indispensable material in waiting for important physiology process, the meeting that be short of zinc produces adverse effect to each system of human body, so zinc by people praise for " the flower of life " .

Microelement has distinct stimulative effect to airframe immunity, as the progress of medical immunology and molecular biology, the happening that had made clear a lot of diseases and development and immunity are concerned mussily, also proved microelement and immunity concern mussily at the same time close. Look into 21 centuries, it is important that immunology cure is sure to develop its increasingly action. Structure of element of microelement zinc itself simple, origin is extensive. Foregone its to airframe a lot of viscera have direct immune unbalance state. Apply its reasonably to change as immune attune the prevention and cure that the agent will come to have a disease, can reduce the poisonous side effect with immune inherent preparation. Reason studies to the immunology of microelement zinc the sense is great, clinical application perspective is wide. Much research confirms; The zincic element influence to airframe immunity function, conduce to the analysis of pair of disease cause of formation already, but from the compensatory microelement with immune pharmacodynamics seasonable, reasonable angle, develop its immunity to adjust to action, achieve the goal of disease of prevention and cure.

Zinc is one of microelement that contain a lot ofinside the cell. The development to immune system, maintain and adjust the effect with a very main move.

Japanese scholar points out: The hyperplasia that is short of zinc to be able to restrain T cell and become divided cause T cell function to damage thereby. Lymphocyte of zincic lack little patient is changed rate under normal children. When the person is short of zinc, the weight of lienal, thymus, lymph node can decrease 20% , 40% , and can make lymphocyte mitotic primary respondent response is abate, t cell decreases and active drops, the leucocyte that has functional active is generated and release decrease, return can brief injury B to drench with cling to cell, the influence is humoral immunity is respondent. And experimental discovery: Total albumen of serum of Guinea pig of the group that be short of zinc under contrast group, among them λ - globulin and albumin relatively contrast the series is outstanding drop. Additionally resource makes clear, clinical on the active of patient thymus element that is short of zinc drops, accompany T cell at the same time inferior group the change with lymphatic factor active, and in element of gland of filling zinc metathorax recoverable normal level. They think, thymus element change is the acute target that human body lacks zinc. Because thymus element is one of factor with stimulative T mature cell, with containing zinc the form of complex matter exists it inside body, the IL-2 that can promote synthesis to have thymus element to depend on accepts put oneself in another's position, adjust IL-2 the action in immune system; At the same time thymus element is returned but the position that action changes IL-2 to accept put oneself in another's position thereby at cellular film, adjust its and inchoate the affinity of the lymphocyte that finalize the design. So zinc is not worth the bring down of thymus element active that cause, be considered as the chief reason of immune function bring down at present.

Zinc is human body inside 200 a variety of enzymatic the important composition composition with protein, also be a lot of enzymatic activator, shared each respects of life activity extensively. Among them the most important zincic is enzymatic have DNA group with protein enzymatic, zinc points to polymerization of enzymatic, RNA albumen transcribe factor, alkalescent phosphoric acid albumen of enzymatic, taste, digest enzymatic etc. Zinc is the active structure composition of these important life macromolecule. DNA polymerization is enzymatic it is one of crucial material with duplicate DNA, aggregate enzymatic amount reduces the DNA when lacking zincic element, active is reduced, bring about DNA duplicate rate to decelerate, the result makes disrupt speed of the cell is reduced even backwater. Zinc lacks the amount that still makes RNA polymerization enzymatic and diminution of quality, affect the expression of gene directly, make afore-mentioned protein that contain zinc and enzymatic synthesis get thereby block up. The become divided of the synthesis that says zinc participates in nucleic acid protein directly so, cell and hyperplasia and a lot of metabolization, there still is the activation of zinc of a few enzymatic needs inside human body, and produce its active effect.

Zinc is about a hundred kinds of enzymatic composition composition and activator, participate in protein and nucleic acid synthesis, the dissension that affects a cell thereby grows and second birth, zinc can quicken teenage growth development, unripe long growth is slow after be short of zinc, stop even, zinc is formed to what collagen organizes, skeleton grows T3 all has T1 translate into immediate effect. Be short of zinc to be able to be brought about grow growth is slow, figure of as a result is short, children intelligence development is undesirable, and body is embedded the children with tall zinc, intelligence is good, study result is admirable, anyhow, zinc can promote the action of intellectual growth, zinc can improve the immune function of body of school age children, maintain and promote the growth of eyesight.

　　 Oaf generation and zincic lack are concerned

Zinc is about a hundred kinds of enzymatic composition composition, the synthesis of these enzymatic the bone suppression that participates in human body, protein metabolization, candy metabolization, RNA and DNA, in fetal grow in development process, all need zinc to attend, so gravid hind should inchoate filling zinc.

Zinc can promote cut heal, enhance immune function. Zinc can promote protein synthesis, mix into fiber cell hyperplasia epithelial form, quicken cut rehabilitate thereby, promote the capability that organizes repair. The expert's research also confirmed this, chroma of patient serum zinc increases, skin-grafting survival rate relatively contrast the group is high, time of the heal that achieve a face also shortens relatively. Patient appetite increases, serous albumen and haemoglobin increase, phenomenon of convert of white ／ ball disappears, cereal third transaminase drops, urea nitrogen returns to normal, protected liver kidney function, conduce to burn achieving the heal of the face, promoted those who burn injury person to restore. Accumulate burn patient to the bedding face of long-term lie in bed, detect serum zinc content is reduced. The discretion of burn skin-grafting survival rate suffers the effect of a variety of elements, opportunity of such as skin-grafting, achieve processing, the application of antibiotic, state of nutrition of patient whole body is main factor. But microelement zinc answers those who cause us to take seriously to the shadow of skin-grafting survival rate. Clinical and preliminary observation: Microelement zinc has the effect that raises burn skin-grafting survival rate, can accelerate the heal that achieve a face, want not seasonable compensatory treatment, be sure to affect skin-grafting to survive with the heal that achieve a face, affect the patient's refreshment.

Zinc is to keep eyesight and the important matter of stimulative eyesight, zinc participates in the vitamin A inside liver and body reductive enzymatic composition, be short of zinc to be able to affect vision so. Night is inspected rely on vitamin A and the supply that inspect yellow aldehyde. Cell of retinal staff state is yellow to making inspect after the long wave is sensitive aldehyde is reductive to inspect Huang Chun. Inspect Huang Chun to be below the action with enzymatic dehydrogenation of the alcohol that contain zinc, second birth restores the sensitive ability to the long wave to inspect yellow aldehyde, the kept normal person night of such go round and round is inspected and dark adaptation ability. When be short of zinc, mellow dehydrogenation enzymatic active is reduced, appear then nyctalopia and dark adaptation ability drop.

Zinc stabilizes biomembrane, improve energy metabolization and haemal perfusion. Can restrain by what iron causes freedom radical generation and fat had been pledged oxidation reacts.

The relationship of zinc and seminal quality and spermatozoon is close, the vivid motivation of the metabolization of spermatozoon of the influence that be short of zinc and spermatozoon, can affect the growth of sexual gland. When old people is short of zinc, memory drops, limb activity obstacle, thinking function is unusual, produce senile domentia even. Zinc has affinity with diseases of a lot of sex of skin mucous membrane, if produce ulcer of stomatitis, glossitis, oral cavity, facial acne, bald hair, lose one's hair to be lacked with zinc,concern, zinc still can affect taste and appetite.

Zinc, copper regards human body as indispensible microelement, its action is with complementary enzymatic, complementary base or the synthesis that the form of activator participates in material, decompose, change. Be in diabetic (in DM) patient blood, most research thinks chroma of its serum zinc drops, heighten of serum copper chroma, heighten of ratio of cupreous ／ zinc, and the progress as DM capillary pathological changes, low zinc, Gaotong is more and more apparent. Copper, zinc makes many sided have mutual Jie to fight action in biochemical metabolization, airframe is short of zinc to be able to make zinc enzymatic kind of synthesis is insufficient, influence red blood cell metabolizes, brittleness of red blood cell increases, be out of shape ability is reduced gather easily, be helpful for forming capillary pathological changes.

Value of zinc of normal person blood is 13.94 μ Mol/L, if regard as under 11.48 μ Mol/L,be short of zincic disease. The 3rd times from our country the data of nutrient reconnaissance survey shows in light of, children is short of zinc or inanition occupies zinc 60%% .

　　 Cause the main reason that zinc lacks

Absorb inadequacy. It is mature that the mother contains zincic quantity to compare in lacteal colostrum breast is tall, after the baby is born, not feed the mother breeds or mother milk is not worth, not timely add rich zinc complementary feed can send zinc to absorb insufficient, our country is a country that gives priority to with corn edibles, rice face kind its contain food establish acid, oxalic acid and cellulose make zincic absorption utilization rate is low, yi Yi causes zinc to lack, have partiality for a particular kind of food, anorexia, carry the bad habit that feed, it is old the main reason that is short of zinc. Content of zinc of prandial structure presence is insufficient, also put in zincic utilization rate to differ, lack zincic occurence rate in our country children so taller. Accordingly, be short of zinc is to cause children bone to grow calcify of slow, bone low, digestive function reduces undesirable, appetite and the main reason of integral stunt. Zinc regards human body as essential mineral element, participated in a variety of life activities inside body, it is very important that to the growth of children development and intelligence develop.

Need quantity increases. Grow growth is rapid, easy appear be short of zinc, metabolism is exuberant make zinc is used up increase. Be in should stimulate condition, the zinc when contracting disease of sex of malignant tumor, infection needs a quantity to increase, the zinc when sufferring from chronic kidney disease, uremia is lost easily.

Absorb use a barrier. Chronic digestibility disease affects zincic absorption to use, be like adipose have diarrhoea, zinc and adipose carbonic acid combine what into indiscerptible complex matter affects zinc to absorb, make contain zinc when enteritis, diarrhoea oozy juice is much eduction. Still congenital zinc blemish waits.

Anyhow, zinc of sufficient understanding microelement gives birth to the action that hit the target in human body, reasonable compensatory zinc, the growth of unbalanced to prepotent actor Yo, precaution, children development, raise disease of the eyesight, stomachic, immunity power that enhances airframe, effective precautionary senile domentia to wait beneficial, to microelement zinc so the action in human body should have enough attention, suggest the guidance that seeks advice from division in health care issues zinc of reasonable and seasonable compensatory microelement, improve our life quality in order to assure.

(The author fastens vice director of vice-president of association of Chinese health care, committee of experts)